Since the last update, I'm really struggling to use 4K files within PS23U. No issues with other editing software on this machine handling that footage, but can't even render a 2 minute clip on PS23U without crashing my machine - blue screen, restart. Am I alone? Any advice on potential resolutions?

What kind of hardware do you have?  4K really pushes the limits of most computers.

CPU: Ryzen 5 2600

RAM: 16 GB

GPU: Radeon RX570 8GB

This system used to rip through renders of 4K files using PS23U before the last update. 

I'm not familiar with amd performance.  I have the i9-9900k with no video card.  I happy with the latest ps 23u editing 4k.  The only slow down is with time remapping.

All AMD user here. No problems at all with anything I toss on the timeline.

Have Task Manager open when you start the software and monitor it to see when it crashes.

Also, in Control Panel, you can reset the software to see if that fixes the issue. 

Here is another way to RESET Pinnacle. This is the one I always use.

Appears to have been resolved by reducing the overclocking on my CPU. Some combination of the PS23U update and a couple Windows 10 updates caused a wide range of different system faults with an OC that had been very stable. Live and learn. Thanks.

Video editors will break an over clock CPU every time.  As the processor ages, you will have to slow it down.  I had to de-lid my i7 and replace the heat sink compound, then it would run PS and photoshop again when it was overclocked.  Too many hours rendering dried it out.

I ran my Ryzen 7 1700X overclocked for several years, but I had it on an AIO (All In One) water cooler. If anything will stress a CPU, it's editing and rendering.

I do have a water cooler for the 3900X, but right now, the supplied (and really great looking) stock cooler is holding it's own.